Abstract Community-acquired pneumonia (CAP) remains a major threat to human health. Data from the United States revealed that 2～3 million cases of CAP occurred annually, and the mortality of hospitalized patients being up to 14%. Therefore, a number of diagnosis and treatment guidelines of CAP based on epidemiological survey  more...

      Abstract Objectives Chronic infection with the hepatitis B virus (HBV) is a major problem of public health and a common disease in our country and currently available therapies have limited efficacy. Gene therapy is a hot point in antiviral therapy. It is a key to get a vector targeted the infected tissues or cell in gene t  more...

      Abstract HFRS is an acute infectious disease caused by hantaviruses which are carried by rodents and shed in the rodent feces and urine. The viruses are transmitted to human through aerosol of rodent excreta.

      Infectious with Hantaan virus (HTNV) can ran  more...

      Abstract Objective: To investigate the clinical rational use of pazufloxacin, a study on the pharmacokinetics and pharmacodynamics of pazufloxacin with 300mg and 500mg was conducted. Methods: 24 healthy volunteers were divided into two groups. Each of them received a single dose and multiple doses of 300mg or 500mg pazufloxac  more...

      ABSTRACT: Part 1: Comparative Anaalysis On Bacterial Resistance Of Isolates Both From Nosocomial Infection and From community Infection in Tianjin during2001-2002 Infectious disease is very common disease in our country and is also leading cause of death. It is inestimable that antibiotic play a very important role in manage  more...

      ABSTRACT There are many varieties of viral hepatitis. Hepatitis B and C are parenterally transmited diseases. Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are globally distributed. It is estimated that about 350 million and 170 million persons worldwide are chronically infected with HBV and HCV, respectively. In China,  more...

      Abstract Hepatitis C virus (HCV) is a single-stranded positive RNA virus belonging to the Flaviviridae family. The HCV genome contains a 5′and a 3′untranslated regions (UTR) and a single open reading frame (ORF) encoding a polypeptide of about 3, 000 amino acids. The polypeptide precursor is cotranslationally and   more...

      ABSTRACT OBJECTIVE: The prevalence of allergic rhinitis (AR) and asthma has increased steadily over the past 3 decades. They are two kinds of common allergic disease endanger the health of human beings and there is a lack of effective prevention and therapeutic measures. Abnormal immunological responses is induced by altere  more...

      ABSTRACT Objective To construct prokaryotic expression vector of Echinococcus multilocularis elp gene, express in Escherichia coli and purify the recombinant protein; To construct eukaryotic expression vector of elp gene, determine the expression ability of the vector by temporary expression in a mammalian cell COS7 and puri  more...

      Abstract Despite the availability of an effective vaccine, infection with hepatitis, B virus (HBV) is still one of the major world health problems. This is mainly due to the fact that more than 350 million people are chronically infected with HBV world wide, who are at high risk of developing liver cirrhosis and hepatocellul  more...